The hand-held ultrasonic pulverizer is a multi-functional and multi-purpose instrument that uses ultrasonic waves to generate cavitation effects in liquids. Used for emulsification, dispersion, homogenization, extraction, defoaming, cleaning, preparation of nanomaterials and acceleration of chemical reactions, etc. The instrument adopts LED display, has automatic and manual (pedal) two working modes, ultrasonic time, power can be set arbitrarily, sample temperature detection display, frequency automatic tracking and other functions. Ultrasonic cell disruption for small volume sample processing